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- <text id=93TT0845>
- <title>
- Sep. 20, 1993: Cold Water on Lorenzo's Oil
- </title>
- <history>
- TIME--The Weekly Newsmagazine--1993
- Sep. 20, 1993 Clinton's Health Plan
- </history>
- <article>
- <source>Time Magazine</source>
- <hdr>
- MEDICINE, Page 76
- Cold Water on Lorenzo's Oil
- </hdr>
- <body>
- <p>Research casts doubt on a Hollywood remedy
- </p>
- <p>By CHRISTINE GORMAN
- </p>
- <p> The popular movie Lorenzo's Oil did more than tout a possible
- cure for a rare and fatal hereditary disease. Based on a true
- story, the 1992 film also vilified the medical establishment
- for being slow to accept the possibility that a combination
- of vegetable oils developed by Augusto and Michaela Odone might
- have improved the condition of their son Lorenzo, 14, who suffers
- from a degenerative nerve illness called adrenoleukodystrophy.
- Now a two-year study from France concludes that the remedy,
- named for the Odones' son, is worthless--at least for the
- milder, adult form of the ailment. Writing in the New England
- Journal of Medicine, Dr. Patrick Aubourg and his colleagues
- from the St. Vincent de Paul Hospital in Paris report that they
- could find no improvement in 24 patients who had taken Lorenzo's
- oil for up to 48 months.
- </p>
- <p> Everyone agrees that Lorenzo's oil cuts down on the level of
- toxic compounds in the blood that are understood to cause the
- disease. But the oil cannot reverse nerve damage, often resulting
- in blindness and paralysis, that has already taken place. Nonetheless,
- Dr. Hugo Moser of the Kennedy Krieger Institute in Baltimore,
- Maryland, believes Lorenzo's oil may delay the onset of symptoms.
- "We know that it's not 100% preventive," says Moser, who is
- conducting a five-year study of 80 boys who have inherited the
- gene for the disease but started taking Lorenzo's oil while
- they are still healthy. "The question that still needs to be
- answered is whether it's partially preventive."
- </p>
-
- </body>
- </article>
- </text>
-
-